Effects of crude leaf extract of Terminalia catappa on parasitaemia and haematology of wistar rats experimentally infected with Trypanosoma brucei brucei

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Original research (Published On: 07-May-2022)

Effects of crude leaf extract of Terminalia catappa on parasitaemia and haematology of wistar rats experimentally infected with Trypanosoma brucei brucei

Ochuko Orakpoghenor, Folashade Sarah Ojeleye, Helen Ileigo Inabo, Clement Myah Zaman Whong, Bolanle Olufunke Priscilla Musa, James Dama Habila and Isaac Asusheyi Bello

J. Vet. Res. Adv., 04 (01):01-08

Ochuko Orakpoghenor: Department of Veterinary Pathology, Ahmadu Bello University

Folashade Sarah Ojeleye: Nigeria Institute of Leather and Science Technology, Zaria, Nigeria; Department of Microbiology, Ahmadu Bello University, Zaria, Nigeria

Helen Ileigo Inabo: Department of Microbiology, Ahmadu Bello University, Zaria, Nigeria

Clement Myah Zaman Whong: Department of Microbiology, Ahmadu Bello University, Zaria, Nigeria

Bolanle Olufunke Priscilla Musa: Immunology Unit, Department of Medicine, Ahmadu Bello University Teaching Hospital Zaria, Nigeria

James Dama Habila: Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria

Isaac Asusheyi Bello: Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria

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Article History: Received on: 28-Jan-22, Accepted on: 01-May-22, Published on: 07-May-22

Corresponding Author: Ochuko Orakpoghenor

Email: ochuko.orakpoghenor@gmail.com

Citation: Ojeleye FS, Inabo HI, Whong CZ, Musa BP, Orakpoghenor O, Habila JD and Bello IA (2022). Effects of crude leaf extract of Terminalia catappa on parasitaemia and haematology of wistar rats experimentally infected with Trypanosoma brucei brucei. J. Vet. Res. Adv., 04 (01):01-08

Abstract

Aim: The study was aimed to evaluate the effects of crude leaf extract of Terminalia catappa on parasitaemia and haematology of Wistar rats experimentally infected with Trypanosoma brucei brucei.

Method and materials: Thirty adult Wistar rats were divided into 6 groups (I-VI), each comprising of 5 rats. Rats in groups I, II, III, IV and V were infected while VI were uninfected. At day 5 post-infection (pi), rats in groups I, II and III were administered crude leaf extract (CE) of Terminalia catappa; group IV administered diminazene aceturate (DA); and V untreated. Blood was collected and monitored for parasitaemia and haematology.

Results: Parasitaemia was detected by 2 days pi, persisted in I, II and III, and completely cleared in group IV at day 10 pi. There were significant (P < 0.05) decreases in packed cells volume, haemoglobin concentration, red and white blood cells, neutrophils and lymphocytes countsin infected groups; followed by significant increases(P < 0.05) post-treatment. The significant increases in haematological parameters following treatment were highest in group IV followed by groups III at day 10 pi.

Conclusion: Crude extract of Terminaliacatappa leaves at dosage of 300 mg/kg did not completely cleared parasitaemia but mitigated changes in haematology induced by T. brucei brucei in Wistar rats following treatment.

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