Abstract

Aim: The main purpose of the study wass to determine the biochemical profile and phytochemical constituents of methanol extract of Carica papaya leaves in albino rats.

Method and materials: To evaluate the effects of the extract on some biochemical parameters, using Diacetyl monoxime method for urea, Jaffe’s method for creatinine, Cholesterol oxidase method for cholesterol, Jendrassik and Grof method for serum bilirubin, Biuret method for total protein, BCG dye binding method for albumin and Glucose oxidase method for fasting glucose. Elemental analysis using SP-9-single beam atomic absorption spectrophotometer (Philips PyeUnicam LTD, England) at the appropriate wavelength, temperature and lamp current for each of the element under study was determined by a standard calibration curve method.

Results: A significant increase (p < 0.05) in urea level was observed in rats treated with 600 mg/kg body weight (28.40 +1.17) compared to the control. There was a significant (p < 0.05) decrease in total protein concentration (5.86 + 0.12) and (5.66 + 0.12) when extract was used at a respectively dose rate of 400 mg/kg and 800 mg/kg body weight compared to control group. Total bilirubin increased significant (p < 0.05) when the extract was used at a dose rate of 800 mg/kg body weight (1.06 + 0.13) compared to control group. Fasting blood glucose level decreased significant (p < 0.05) in all test groups compared to control.

Conclusion: It was concluded that the leaves of Carica papaya contains bioactive phytochemical constituents that could have clinical potential with safe medicinal properties.

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